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Tero Toivanen

Scientists capture the first image of memories being made - 0 views

www.eurekalert.org/...mu-sct061809.php

brain memory protein translation long-term memory proteins synapse synaptic connection learning synaptic plasticity post-synaptic cell neurons

shared by Tero Toivanen on 21 Jun 09 - Cached
  • A new study by researchers at the Montreal Neurological Institute and Hospital (The Neuro), McGill University and University of California, Los Angeles has captured an image for the first time of a mechanism, specifically protein translation, which underlies long-term memory formation. The finding provides the first visual evidence that when a new memory is formed new proteins are made locally at the synapse - the connection between nerve cells - increasing the strength of the synaptic connection and reinforcing the memory. The study published in Science, is important for understanding how memory traces are created and the ability to monitor it in real time will allow a detailed understanding of how memories are formed.
  • research has focused on synapses which are the main site of exchange and storage in the brain.
  • They form a vast but also constantly fluctuating network of connections whose ability to change and adapt, called synaptic plasticity, may be the fundamental basis of learning and memory.
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  • Using a translational reporter, a fluorescent protein that can be easily detected and tracked, we directly visualized the increased local translation, or protein synthesis, during memory formation.
  • Importantly, this translation was synapse-specific and it required activation of the post-synaptic cell, showing that this step required cooperation between the pre and post-synaptic compartments, the parts of the two neurons that meet at the synapse.
  • This study provides evidence that a mechanism that mediates this gene expression during neuronal plasticity involves regulated translation of localized mRNA at stimulated synapses.
  • Tero Toivanen on 21 Jun 09
     
    A new study by researchers at the Montreal Neurological Institute and Hospital (The Neuro), McGill University and University of California, Los Angeles has captured an image for the first time of a mechanism, specifically protein translation, which underlies long-term memory formation.
Tero Toivanen

Neurophilosophy : Experience induces global reorganization of brain circuitry - 0 views

scienceblogs.com/...ization_of_brain_circuitry.php

neurophilosophy brain LTP learning memory

shared by Tero Toivanen on 23 May 09 - Cached
  • Now referred to as long-term potentiation (LTP), this mechanism has since become the most intensively studied in modern neuroscience,and is widely believed to be the cellular basis of learning and memory, although this is yet to be proven unequivocally.
  • In the new study, Santiago Canals of the Max Planck Institute for Biological Cybernetics in Tübingen and his colleagues used the same protocol to induce LTP. But while the vast majority of researchers have investigated LTP in slices of hippocampal tissue, this study involved observing LTP in live animals.
  • This new research provides the first evidence that the local modifications in synaptic connections induced by LTP lead to long-lasting changes in the activity of a diffuse network of brain regions, and even to facilitated communication between the two hemispheres. The fMRI data showed that hippocampal LTP recruits higher order association areas, as well as regions involved in emotions and others subserving different sensory modalities, all of which are known to be involved in memory formation.
  • Tero Toivanen on 23 May 09
     
    Experience induces global reorganization of brain circuitry. This new research provides the first evidence that the local modifications in synaptic connections induced by LTP lead to long-lasting changes in the activity of a diffuse network of brain regions, and even to facilitated communication between the two hemispheres.
David McGavock

Scientific Understanding of Consciousness - 0 views

willcov.com/bio-consciousness

understanding consciousness experts writers summary

shared by David McGavock on 02 Mar 14 - No Cached
  • During the past 20 years or so, biological sciences have advanced to the point that scientists have begun researching biological mechanisms of brain function and suggesting some reasonably well-founded hypotheses for consciousness. Leading the way in these pioneering efforts, in my judgment, have been:   Gerald Edelman with his hypothesis of the Dynamic Core, Antonio Damasio with his concepts of  Protoself, Core Self, Autobiographical Self, Core Consciousness and Extended Consciousness, Joseph LeDoux and his emphasis on the intricacies of synapses and the emotional brain,
  • Rudolfo Llinás and his researches into ~40 Hz oscillations and synchronization, György Buzsáki with his discussion and exploration of neural mechanisms related to oscillation and synchronization in the neocortex and hippocampus for perception and memory, Joaquín Fuster, the world’s preeminent expert on the frontal lobes, and his concept of the "perception-action cycle," Susan Greenfield's notion of "neuronal gestalts" as a way of conceptualizing a highly variable aggregation of neurons that is temporarily recruited around a triggering epicenter. I use the neuronal gestalts idea in my way of visualizing the functionality of the dynamic core of the thalamocortical system, Eric Kandel who has explored short-term and long-term memory,
  • The late Francis Crick with his collaborator Christof Koch who have pursued the neural correlate of consciousness (NCC), Michael Gazzaniga with the concept of the left hemisphere ‘interpreter’ unifying consciousness experience, Edmund Rolls and Gustavo Deco with their mathematical models of brain function using information theory approaches for biologically plausible neurodynamical modeling of cognitive phenomena corroborated by brain imaging studies, David LaBerge with his discussion of the thalamocortical circuit and attention, Alan Baddeley who continues to refine his model for working memory, Philosopher John Searle who endorses the idea that consciousness is an emergent property of neural networks.
  • David McGavock on 02 Mar 14
     
    "My objective in this website has been to bring together salient features of these assorted interpretations by science experts into a synthesis of my own understanding of consciousness. I consider these statements and interpretations to be a framework on which to build a fuller understanding as further data, concepts and insights develop from ongoing research."
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